It is important to ask how and if string theory can describe what may turn out to be a non-supersymmetric world. What particular issues does lack of (space-time) supersymmetry bring, and to what extent can they be avoided? How might one build a Standard Model? Are there any particular requirements or even predictions coming from consistency, and what happens in such theories to the hierarchy problem? In this talk I will give a summary of recent and ongoing progress in non-supersymmetric string phenomenology, in which we make first attempts to address these questions.